What is a major symptom of Tay-Sachs disease?

A major symptom of Tay-Sachs disease is muscle weakness, which occurs as a result of the gradual degeneration of nerve cells in the brain and spinal cord. This genetic disorder is caused by a deficiency of the enzyme hexosaminidase A, leading to an accumulation of harmful substances in the cells. As the disease progresses, the nervous system's function deteriorates, significantly affecting motor skills and causing weakness in the muscles.

The other options do not accurately reflect the symptoms associated with Tay-Sachs disease; for example, individuals with this condition do not experience growth spurts or increased vision. Rapid body temperature changes are also not characteristic of this disease. Overall, muscle weakness is a clear and evident symptom indicative of the neural decline associated with Tay-Sachs.